• Amebiasis (Entamoeba histolytica/dispar) 
• Anaplasmosis 
• Anthrax 
• Arboviral disease 
• Babesiosis 
• Blastomycosis 
• Botulism 
• Brucellosis 
• Campylobacteriosis 
• Cat scratch disease 
• Chancroid 
• Chlamydia  
• Cholera 
• Coccidioidomycosis 
• Cryptosporidiosis 
• Cyclosporiasis 
• Dengue virus infection 
• Diphtheria 
• Diphyllobothrium latum 
• Ehrlichiosis 
• Encephalitis (caused by viral agents) 
• Enterobacter sakazakii 
• Enteric E. coli infection 
• Giardiasis 
• Gonorrhea 
• Haemophilus influenzae disease (all invasive disease) 
• Hantavirus infection 
• Hemolytic uremic syndrome 
• Hepatitis (all viral types) 
• Histoplasmosis 
• Human immunodeficiency virus (HIV) infection including Acquired Immunodeficiency Syndrome (AIDS) 
• Influenza (unusual case incidence, critical illness, or laboratory confirmed cases) 
• Kawasaki disease  
• Kingella spp. 
• Legionellosis 
• Leprosy (Hansen’s disease) 
• Leptospirosis 
• Listeriosis 
• Lyme disease 
• Malaria 
• Measles 
• Meningitis (caused by viral agents) 
• Meningococcal disease (Neisseria meningitidis) 
• Mumps 
• Neonatal Sepsis 
• Orthopox virus 
• Pertussis 
• Plague 
• Poliomyelitis 
• Psittacosis 
• Q fever 
• Rabies 
• Retrovirus infections (other than HIV) 
• Reye syndrome 
• Rheumatic fever 
• Rocky Mountain spotted fever 
• Rubella and congenital rubella syndrome 
• Salmonellosis (including typhoid) 
• Severe Acute Respiratory Syndrome (SARS) 
  • Includes SARS-CoV-2 (COVID-19) 
• Shigellosis 
• Smallpox 
• Staphylococcus aureus (special situations involving vancomycin resistance or death or critical illness in an otherwise healthy individual) 
• Streptococcal disease (invasive disease) 
• Syphilis 
• Tetanus 
• Toxic shock syndrome 
• Toxoplasmosis 
• Transmissible spongiform encephalopathy 
• Trichinosis 
• Tuberculosis 
• Tularemia  
• Typhus 
• Unexplained deaths and unexplained critical illness (possibly due to an infectious cause) 
• Varicella-zoster disease (primary (chickenpox) and recurrent (shingles)) 
• Vibrio spp. 
• Yellow fever 
• Yersiniosis 

Unusual or increased case incidence of any suspect infectious illness is also reportable